PhD Researcher in Stem Cell Immunotherapy (Healthcare, Remote)

Job summary

This PhD position focuses on advancing T cell therapies through the differentiation of T cells from inducible pluripotent stem cells (iPSCs). The role involves collaboration in an interdisciplinary environment to develop innovative immunotherapy solutions aimed at tackling critical healthcare challenges.

Qualifications

• MSc in biotechnology, immunology, pharmaceutical design, engineering, or a related field.
• Proficient in molecular biology techniques and cell culture systems.
• Strong foundation in T cell immunology.
• Experience with flow cytometry.
• Familiarity with stem cell culturing and iPSC maintenance.
• Preferably experienced in iPSC to T cell differentiation protocols.
• Proven ability in scientific communication and teamwork.

Responsibilities

• Develop and validate nanoparticle-based biomaterials for T cell differentiation.
• Select ligands for T cell interactions and optimize nanoparticle designs.
• Test new solutions against existing T cell differentiation protocols.
• Conduct genetic engineering of iPSC lines to express CARs or TCRs.
• Perform in vitro functional validation of iPSC-derived T cell products.
• Assess therapeutic efficacy using cancer cell line models.
• Execute and analyze pre-clinical in vivo experiments.
• Document and present results through scientific publications.

Education

• A two-year master's degree (120 ECTS points) or equivalent academic level is required.

Tools

• Experience with flow cytometry and molecular biology tools is essential.